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In the presence of small cyclic alcohols (like phenol, cresol, resorcinol, hexanol, and pentanol), the insulin hexamer exhibits the R 6 state with the B-chain residues (Phe1 to Cys19) of each monomer adapting an helical conformation ( Figure 2C )

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The 1% concentration range used in most published clinical trials sits at the level demonstrated to produce dermal effects while maintaining a formulation viscosity optimized for absorption

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